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HomoloGene:725. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

POR,  H.sapiens
P450 (cytochrome) oxidoreductase
NP_000932.3
680 aa
POR,  P.troglodytes
P450 (cytochrome) oxidoreductase
XP_001155755.2
680 aa
POR,  M.mulatta
P450 (cytochrome) oxidoreductase
XP_001109664.1
680 aa
POR,  C.lupus
P450 (cytochrome) oxidoreductase
NP_001171276.1
678 aa
POR,  B.taurus
P450 (cytochrome) oxidoreductase
NP_001030467.1
680 aa
Por,  M.musculus
P450 (cytochrome) oxidoreductase
NP_032924.1
678 aa
Por,  R.norvegicus
P450 (cytochrome) oxidoreductase
NP_113764.1
678 aa
POR,  G.gallus
P450 (cytochrome) oxidoreductase
NP_001182725.1
676 aa
por,  X.tropicalis
P450 (cytochrome) oxidoreductase
XP_002933864.1
680 aa
por,  D.rerio
P450 (cytochrome) oxidoreductase
NP_001030154.1
674 aa
Cpr,  D.melanogaster
Cytochrome P450 reductase
NP_001260128.1
679 aa
emb-8,  C.elegans
emb-8
NP_498103.1
662 aa
NCP1,  S.cerevisiae
NCP1
NP_011908.1
691 aa
KLLA0D08712g,  K.lactis
KLLA0D08712g
XP_453451.1
699 aa
AGOS_AAL121C,  E.gossypii
AGOS_AAL121C
NP_982421.1
688 aa
ccr1,  S.pombe
ccr1
NP_596046.1
678 aa
MGG_07117,  M.oryzae
MGG_07117
XP_003715306.1
690 aa
NCU09741,  N.crassa
NCU09741
XP_964443.1
692 aa
ATR2,  A.thaliana
ATR2
NP_849472.2
712 aa
Os09g0558900,  O.sativa
Os09g0558900
NP_001063914.1
714 aa
Os08g0243500,  O.sativa
Os08g0243500
NP_001061346.1
651 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adrenal hyperplasia, congenital, due to combined P450C17 and P450C21 deficiency.
Antley-Bixler syndrome-like with disordered steroidogenesis.
Disordered steroidogenesis, isolated.
POR deficiency.



Publications
Articles associated with genes and sequences of this homology group.

NADPH P450 oxidoreductase: structure, function, and pathology of diseases.
Pandey AV & Flück CE. Pharmacol Ther 138, 229-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FMN_red (cl00438)
  NADPH-dependent FMN reductase.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Por includes H.sapiens POR and R.norvegicus Por.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (15 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (40 transcripts, 27 species)
Liliopsida - monocots (3 transcripts, 2 species)
Bryopsida - mosses (3 transcripts, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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