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HomoloGene:7977. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

MYO18A,  H.sapiens
myosin XVIIIA
2039 aa
MYO18A,  M.mulatta
myosin XVIIIA
2039 aa
MYO18A,  C.lupus
myosin XVIIIA
2481 aa
MYO18A,  B.taurus
myosin XVIIIA
2055 aa
Myo18a,  M.musculus
myosin XVIIIA
2035 aa
Myo18a,  R.norvegicus
myosin XVIIIa
2054 aa
MYO18A,  G.gallus
myosin XVIIIA
2475 aa
myo18ab,  D.rerio
myosin XVIIIAb
2514 aa
myo18aa,  D.rerio
myosin XVIIIAa
2454 aa
Mhcl,  D.melanogaster
Myosin heavy chain-like
2160 aa
AgaP_AGAP011138,  A.gambiae
1909 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Mammalian myosin-18A, a highly divergent myosin.
Guzik-Lendrum S, et al. J Biol Chem 288, 9532-48 (2013).
Subcellular localization and dynamics of MysPDZ (Myo18A) in live mammalian cells.
Mori K, et al. Biochem Biophys Res Commun 326, 491-8 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Jnk-SapK_ap_N (pfam09744)
  JNK_SAPK-associated protein-1.
Trichoplein (pfam13868)
  Tumour suppressor, Mitostatin.
IQ (cl15479)
  IQ calmodulin-binding motif.
DUF827 (pfam05701)
  Plant protein of unknown function (DUF827).
Spc24 (pfam08286)
  Spc24 subunit of Ndc80.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
SPEC (cl02488)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
ATP-synt_B (cl17192)
  ATP synthase B/B' CF(0).
NBP1 (pfam08537)
  Fungal Nap binding protein NBP1.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo18a includes H.sapiens MYO18A.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (25 transcripts, 7 species)
Mammalia - mammals (14 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Demospongiae - sponges (2 transcripts, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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