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HomoloGene:55679. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRKCA,  H.sapiens
protein kinase C, alpha
NP_002728.1
672 aa
PRKCA,  P.troglodytes
protein kinase C, alpha
XP_003315734.1
672 aa
PRKCA,  M.mulatta
protein kinase C, alpha
XP_002800615.1
672 aa
PRKCA,  C.lupus
protein kinase C, alpha
XP_005624328.1
659 aa
PRKCA,  B.taurus
protein kinase C, alpha
NP_776860.1
672 aa
Prkca,  M.musculus
protein kinase C, alpha
NP_035231.2
672 aa
Prkca,  R.norvegicus
protein kinase C, alpha
NP_001099183.1
636 aa
PRKCA,  G.gallus
protein kinase C, alpha
NP_001012822.1
674 aa
LOC101749801,  G.gallus
protein kinase C alpha type-like
XP_004946286.1
682 aa
prkca,  X.tropicalis
protein kinase C, alpha
NP_001072752.1
678 aa
prkca,  D.rerio
protein kinase C, alpha
NP_001243170.1
670 aa
Pkc53E,  D.melanogaster
Protein C kinase 53E
NP_725626.1
679 aa
AgaP_AGAP012252,  A.gambiae
AgaP_AGAP012252
XP_320290.4
684 aa
pkc-2,  C.elegans
pkc-2
NP_001024518.1
936 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for protein kinase C (PKC) that is expressed primarily in the brain of adult flies.

H.sapiens
Pituitary tumor, invasive.



Publications
Articles associated with genes and sequences of this homology group.

Serum protein kinase Cα as a diagnostic biomarker of cancers.
Kang JH, et al. Cancer Biomark 13, 99-103 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkca includes H.sapiens PRKCA and R.norvegicus Prkca.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (21 transcripts, 6 species)
Mammalia - mammals (13 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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