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HomoloGene:2168. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RASA1,  H.sapiens
RAS p21 protein activator (GTPase activating protein) 1
NP_002881.1
1047 aa
RASA1,  P.troglodytes
RAS p21 protein activator (GTPase activating protein) 1
XP_517663.3
1047 aa
RASA1,  M.mulatta
RAS p21 protein activator (GTPase activating protein) 1
XP_001084074.2
1040 aa
RASA1,  C.lupus
RAS p21 protein activator (GTPase activating protein) 1
XP_536302.3
1024 aa
RASA1,  B.taurus
RAS p21 protein activator (GTPase activating protein) 1
NP_776874.1
1044 aa
Rasa1,  M.musculus
RAS p21 protein activator 1
NP_663427.2
1038 aa
Rasa1,  R.norvegicus
RAS p21 protein activator (GTPase activating protein) 1
NP_037267.1
1038 aa
RASA1,  G.gallus
RAS p21 protein activator (GTPase activating protein) 1
XP_424907.4
1120 aa
LOC100135092,  X.tropicalis
uncharacterized LOC100135092
NP_001107303.1
946 aa
rasa1a,  D.rerio
RAS p21 protein activator 1a
XP_001342009.2
1010 aa
vap,  D.melanogaster
vacuolar peduncle
NP_727926.2
954 aa
AgaP_AGAP002729,  A.gambiae
AgaP_AGAP002729
XP_312197.3
948 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Basal cell carcinoma, somatic.
Capillary malformation-arteriovenous malformation.
Parkes Weber syndrome.



Publications
Articles associated with genes and sequences of this homology group.

RASA1 analysis: clinical and molecular findings in a series of consecutive cases.
Wooderchak-Donahue W, et al. Eur J Med Genet 55, 91-5 (2012).
RASA1-Related Disorders
Bayrak-Toydemir P, et al. (1993).
A novel association between RASA1 mutations and spinal arteriovenous anomalies.
Thiex R, et al. AJNR Am J Neuroradiol 31, 775-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH_RasGAP_CG5898 (cd01245)
  RAS GTPase-activating protein (GAP) CG5898 Pleckstrin homology (PH) domain.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
C2 (cl14603)
  C2 domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rasa1 includes H.sapiens RASA1 and R.norvegicus Rasa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 14 species)
Actinopterygii - bony fishes (17 transcripts, 8 species)
Aves - birds (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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