Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:30950. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

APC,  H.sapiens
adenomatous polyposis coli
NP_001120982.1
2843 aa
APC,  P.troglodytes
adenomatous polyposis coli
XP_001143965.1
2844 aa
APC,  C.lupus
adenomatous polyposis coli
XP_005618091.1
2843 aa
APC,  B.taurus
adenomatous polyposis coli
NP_001069454.2
2851 aa
Apc,  M.musculus
adenomatosis polyposis coli
NP_031488.2
2842 aa
Apc,  R.norvegicus
adenomatous polyposis coli
NP_036631.1
2842 aa
APC,  G.gallus
adenomatous polyposis coli
XP_004949340.1
2841 aa
apc,  X.tropicalis
adenomatous polyposis coli
XP_004910521.1
2833 aa
apc,  D.rerio
adenomatosis polyposis coli
NP_001137312.1
2754 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Desmoid disease, hereditary.
Gastric cancer.
Medulloblastoma.
Adenoma, periampullary.
Adenomatous polyposis coli.
Adenomatous polyposis coli, attenuated.
Colorectal cancer.
Gardner syndrome.
Turcot syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Wnt signaling potentiates nevogenesis.
Pawlikowski JS, et al. Proc Natl Acad Sci U S A 110, 16009-14 (2013).
Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors.
Thliveris AT, et al. Proc Natl Acad Sci U S A 110, 11523-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EB1_binding (pfam05937)
  EB-1 Binding Domain.
APC_crr (pfam05923)
  APC cysteine-rich region.
SAMP (pfam05924)
  SAMP Motif.
Suppressor_APC (pfam11414)
  Adenomatous polyposis coli tumor suppressor protein.
APC_basic (pfam05956)
  APC basic domain.
ARM (cd00020)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
ARM (cl02500)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
APC_basic (pfam05956)
  APC basic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apc includes H.sapiens APC and R.norvegicus Apc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

Support Center