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HomoloGene:47947. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ATP1A2,  H.sapiens
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_000693.1
1020 aa
ATP1A2,  P.troglodytes
ATPase, Na+/K+ transporting, alpha 2 polypeptide
XP_513921.2
999 aa
ATP1A2,  M.mulatta
ATPase, Na+/K+ transporting, alpha 2 polypeptide
XP_001115318.2
1020 aa
ATP1A2,  C.lupus
ATPase, Na+/K+ transporting, alpha 2 polypeptide
XP_545753.3
1020 aa
ATP1A2,  B.taurus
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_001074993.1
1020 aa
Atp1a2,  M.musculus
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_848492.1
1020 aa
Atp1a2,  R.norvegicus
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_036637.1
1020 aa
ATP1A2,  G.gallus
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_990807.1
1017 aa
atp1a2,  X.tropicalis
ATPase, Na+/K+ transporting, alpha 2 polypeptide
NP_001096439.1
1020 aa
atp1a2a,  D.rerio
ATPase, Na+/K+ transporting, alpha 2a polypeptide
NP_571758.1
1017 aa
MGG_16361,  M.oryzae
MGG_16361
XP_003710305.1
1107 aa
MGG_10027,  M.oryzae
MGG_10027
XP_003717477.1
1100 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alternating hemiplegia of childhood.
Migraine, familial basilar.
Migraine, familial hemiplegic, 2.



Publications
Articles associated with genes and sequences of this homology group.

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.
Swarts HG, et al. Biochim Biophys Acta 1832, 2173-9 (2013).
Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2).
Barros J, et al. J Headache Pain 13, 581-5 (2012).
Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation.
Iizuka T, et al. J Neurol Neurosurg Psychiatry 83, 205-12 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cl11391)
  Haloacid Dehalogenase-like Hydrolases.
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
COG4087 (COG4087)
  Soluble P-type ATPase [General function prediction only].
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
Cation_ATPase_N (cl02930)
  Cation transporter/ATPase, N-terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atp1a2 includes H.sapiens ATP1A2 and R.norvegicus Atp1a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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