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HomoloGene:810. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCN1B,  H.sapiens
sodium channel, voltage-gated, type I, beta subunit
NP_001028.1
218 aa
SCN1B,  P.troglodytes
sodium channel, voltage-gated, type I, beta subunit
NP_001104291.1
218 aa
SCN1B,  M.mulatta
sodium channel, voltage-gated, type I, beta subunit
XP_001093023.1
218 aa
SCN1B,  C.lupus
sodium channel, voltage-gated, type I, beta subunit
NP_001020569.1
218 aa
SCN1B,  B.taurus
sodium channel, voltage-gated, type I, beta subunit
NP_001069964.1
218 aa
Scn1b,  M.musculus
sodium channel, voltage-gated, type I, beta
NP_035452.1
218 aa
Scn1b,  R.norvegicus
sodium channel, voltage-gated, type I, beta subunit
NP_001257974.1
218 aa
scn1b,  X.tropicalis
sodium channel, voltage-gated, type I, beta subunit
XP_004916468.1
211 aa
scn1ba,  D.rerio
sodium channel, voltage-gated, type I, beta a
NP_001071007.1
221 aa
scn1bb,  D.rerio
sodium channel, voltage-gated, type I, beta b
NP_001121628.1
222 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Generalized epilepsy with febrile seizures plus.



Publications
Articles associated with genes and sequences of this homology group.

Do mutations in SCN1B cause Dravet syndrome?
Kim YO, et al. Epilepsy Res 103, 97-100 (2013).
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.
Nguyen HM, et al. Proc Natl Acad Sci U S A 109, 18577-82 (2012).
Identification of an intra-molecular disulfide bond in the sodium channel β1-subunit.
Barbieri R, et al. Biochem Biophys Res Commun 420, 364-7 (2012).
Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo.
Lopez-Santiago LF, et al. J Biol Chem 286, 22913-23 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
V-set (pfam07686)
  Immunoglobulin V-set domain.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn1b includes H.sapiens SCN1B and R.norvegicus Scn1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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