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HomoloGene:37912. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CASP3,  H.sapiens
caspase 3, apoptosis-related cysteine peptidase
NP_004337.2
277 aa
CASP3,  P.troglodytes
caspase 3, apoptosis-related cysteine peptidase
NP_001012435.1
277 aa
CASP3,  M.mulatta
caspase 3, apoptosis-related cysteine peptidase
XP_001083044.1
277 aa
CASP3,  C.lupus
caspase 3, apoptosis-related cysteine peptidase
NP_001003042.1
277 aa
CASP3,  B.taurus
caspase 3, apoptosis-related cysteine peptidase
NP_001071308.1
275 aa
Casp3,  M.musculus
caspase 3
NP_001271338.1
277 aa
Casp3,  R.norvegicus
caspase 3
NP_037054.1
277 aa
CASP3,  G.gallus
caspase 3, apoptosis-related cysteine peptidase
NP_990056.1
283 aa
casp3,  X.tropicalis
caspase 3, apoptosis-related cysteine peptidase
NP_001120900.1
288 aa
CASPS8,  A.gambiae
CASPS8
XP_318945.3
294 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Active caspase-3 is stored within secretory compartments of viable mast cells.
Garcia-Faroldi G, et al. J Immunol 191, 1445-52 (2013).
[Association of new functional SNP rs72689236 of CASP3 with Kawasaki disease: a meta-analysis].
Peng Q, et al. Zhongguo Dang Dai Er Ke Za Zhi 15, 477-83 (2013).
Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles.
Böing AN, et al. Biochim Biophys Acta 1833, 1844-52 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CASc (cl00042)
  Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Casp3 includes H.sapiens CASP3 and R.norvegicus Casp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 15 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (5 transcripts, 1 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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