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HomoloGene:8156. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MUTYH,  H.sapiens
mutY homolog
NP_001041636.1
535 aa
MUTYH,  P.troglodytes
mutY homolog (E. coli)
XP_001155582.3
534 aa
MUTYH,  M.mulatta
mutY homolog (E. coli)
XP_001101555.2
537 aa
MUTYH,  C.lupus
mutY homolog
XP_003639574.1
563 aa
MUTYH,  B.taurus
mutY homolog (E. coli)
NP_001039600.2
526 aa
Mutyh,  M.musculus
mutY homolog (E. coli)
NP_001153053.1
515 aa
Mutyh,  R.norvegicus
mutY homolog
NP_579850.1
516 aa
MUTYH,  G.gallus
mutY homolog (E. coli)
XP_004936806.1
521 aa
mutyh,  X.tropicalis
mutY homolog
NP_001072831.1
520 aa
mutyh,  D.rerio
mutY homolog (E. coli)
XP_686698.2
526 aa
myh1,  S.pombe
myh1
NP_594145.1
461 aa
AT4G12740,  A.thaliana
AT4G12740
NP_193010.2
630 aa
Os12g0211400,  O.sativa
Os12g0211400
NP_001066403.1
474 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas.
Gastric cancer, somatic.
Adenomas, multiple colorectal.



Publications
Articles associated with genes and sequences of this homology group.

Understanding the role of the Q338H MUTYH variant in oxidative damage repair.
Turco E, et al. Nucleic Acids Res 41, 4093-103 (2013).
MUTYH-Associated Polyposis
Nielsen M, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EndIII_4Fe-2S (cl15304)
  Iron-sulfur binding domain of endonuclease III.
Nudix_Hydrolase (cl00447)
  Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
EndIII_4Fe-2S (cl15304)
  Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease.
ENDO3c (cl19066)
  endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mutyh includes H.sapiens MUTYH and R.norvegicus Mutyh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (6 transcripts, 6 species)
Liliopsida - monocots (4 transcripts, 4 species)

 

 

 

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