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HomoloGene:100530. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HK1,  H.sapiens
hexokinase 1
NP_000179.2
917 aa
HK1,  P.troglodytes
hexokinase 1
XP_001169264.2
971 aa
HK1,  M.mulatta
hexokinase 1
XP_001110396.2
920 aa
HK1,  C.lupus
hexokinase 1
XP_536376.3
917 aa
HK1,  B.taurus
hexokinase 1
NP_001012686.1
917 aa
Hk1,  M.musculus
hexokinase 1
NP_001139572.1
918 aa
Hk1,  R.norvegicus
hexokinase 1
NP_036866.1
918 aa
HK1,  G.gallus
hexokinase 1
NP_989432.1
917 aa
hk1,  X.tropicalis
hexokinase 1
NP_001096201.1
917 aa
hk1,  D.rerio
hexokinase 1
NP_998417.1
918 aa
Hex-t2,  D.melanogaster
Hex-t2
NP_733151.2
486 aa
Hex-C,  D.melanogaster
Hexokinase C
NP_524674.1
454 aa
Hex-A,  D.melanogaster
Hexokinase A
NP_524848.1
541 aa
HXK1,  S.cerevisiae
HXK1
NP_116711.3
485 aa
HXK2,  S.cerevisiae
HXK2
NP_011261.1
486 aa
KLLA0D11352g,  K.lactis
KLLA0D11352g
XP_453567.1
485 aa
AGOS_AFR279C,  E.gossypii
AGOS_AFR279C
NP_985826.1
488 aa
hxk1,  S.pombe
hxk1
NP_592948.1
484 aa
MGG_09289,  M.oryzae
MGG_09289
XP_003709938.1
481 aa
NCU02542,  N.crassa
NCU02542
XP_965673.2
489 aa
HXK2,  A.thaliana
HXK2
NP_179576.1
502 aa
HXK1,  A.thaliana
HXK1
NP_194642.1
496 aa
Os05g0522500,  O.sativa
Os05g0522500
NP_001056082.1
507 aa
Os01g0742500,  O.sativa
Os01g0742500
NP_001044214.1
506 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The structural gene for hexokinase-C (HEX-C). The enzyme is a monomer of estimated molecular weight 42,000 +/- 3,000 (Moser et al.) or 35,000 (Leigh Brown in Racine, Langley and Voelker, 1980). Activity present in all developmental stages except freshly laid eggs; restricted to fat body in larvae, but present in many organs in adult. Weakly active or inactive in cell line (Debec, 1974). HEX-C activity not necessary for survival; null mutants viable (Burkhart et al., 1984). Purification and biochemical characterization of enzyme described by Moser et al., 1980..
The structural gene for hexokinases A, B1 and B2. The enzyme is monomeric and of molecular weight 47,000 +/- 3000 for HEX-A and 48,000 +/- 3000 for HEX-B1 and HEX-B2. The three forms of the enzyme are immunologically identical but exhibit pI values of 5.1, 5.3 and 5.5 respectively upon isoelectric focusing, and these values covary in allelic variants. All three forms are found in the adult, but HEX-A is absent from larval preparations; HEX-A mainly localized in adult flight muscle. Three forms modified products of same structural gene. (See FlyBase for complete description.)

H.sapiens
Hemolytic anemia due to hexokinase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Dominant form of congenital hyperinsulinism maps to HK1 region on 10q.
Pinney SE, et al. Horm Res Paediatr 80, 18-27 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.
ArsR (cl19623)
  ArsR transcriptional regulator.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hk1 includes H.sapiens HK1 and R.norvegicus Hk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (23 transcripts, 15 species)
Liliopsida - monocots (10 transcripts, 7 species)
Coniferopsida - conifers (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (14 transcripts, 6 species)
Mammalia - mammals (11 transcripts, 11 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (13 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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