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HomoloGene:55940. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTHFD1,  H.sapiens
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_005947.3
935 aa
MTHFD1,  P.troglodytes
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
XP_510001.3
1016 aa
MTHFD1,  M.mulatta
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
XP_001101708.2
1042 aa
MTHFD1,  C.lupus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
XP_537476.2
935 aa
MTHFD1,  B.taurus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_001076946.1
935 aa
Mthfd1,  M.musculus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
NP_620084.2
935 aa
Mthfd1,  R.norvegicus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_071953.1
935 aa
MTHFD1,  G.gallus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_001034392.1
935 aa
mthfd1,  X.tropicalis
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_001008007.1
934 aa
mthfd1b,  D.rerio
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
NP_955823.1
934 aa
pug,  D.melanogaster
pugilist
NP_731489.2
968 aa
AgaP_AGAP002830,  A.gambiae
AgaP_AGAP002830
XP_312083.5
937 aa
K07E3.4,  C.elegans
K07E3.4
NP_509360.1
640 aa
ADE3,  S.cerevisiae
ADE3
NP_011720.3
946 aa
KLLA0E16545g,  K.lactis
KLLA0E16545g
XP_454695.1
947 aa
AGOS_ACL121C,  E.gossypii
AGOS_ACL121C
NP_983283.2
939 aa
SPBC839.16,  S.pombe
SPBC839.16
NP_595256.1
937 aa
MGG_01014,  M.oryzae
MGG_01014
XP_003717930.1
1074 aa
NCU03877,  N.crassa
NCU03877
XP_956550.1
941 aa
THFS,  A.thaliana
THFS
NP_564571.1
634 aa
Os09g0446800,  O.sativa
Os09g0446800
NP_001063310.1
707 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Abruptio placentae, susceptibility to.
Spina bifida, folate-sensitive, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Head and neck carconogenesis: impact of MTHFD1 G1958A polymorphism.
Silva LM, et al. Rev Assoc Med Bras (1992) 57, 194-9 (2011).
A neonate with antiphospholipid syndrome and inherited thrombophilia.
Canpolat FE & Cekmez F. Pediatr Hematol Oncol 28, 251-2 (2011).
The MTHFD1 c.1958 G>A polymorphism and recurrent spontaneous abortions.
Cri┼čan TO, et al. J Matern Fetal Neonatal Med 24, 189-92 (2011).
Analysis of the MTHFD1 promoter and risk of neural tube defects.
Carroll N, et al. Hum Genet 125, 247-56 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
THF_DHG_CYH (pfam00763)
  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain.
FolD (COG0190)
  5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism].
THF_DHG_CYH (pfam00763)
  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain.
Fer4_NifH (cl17203)
  The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.
NAD_bind_amino_acid_DH (cl17226)
  NAD(P) binding domain of amino acid dehydrogenase-like proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mthfd1 includes H.sapiens MTHFD1 and R.norvegicus Mthfd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (51 transcripts, 32 species)
Liliopsida - monocots (18 transcripts, 8 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Actinopterygii - bony fishes (18 transcripts, 10 species)
Mammalia - mammals (16 transcripts, 14 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (6 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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