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HomoloGene:842. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PDE5A,  H.sapiens
phosphodiesterase 5A, cGMP-specific
875 aa
PDE5A,  P.troglodytes
phosphodiesterase 5A, cGMP-specific
921 aa
PDE5A,  M.mulatta
phosphodiesterase 5A, cGMP-specific
875 aa
PDE5A,  C.lupus
phosphodiesterase 5A, cGMP-specific
833 aa
PDE5A,  B.taurus
phosphodiesterase 5A, cGMP-specific
865 aa
Pde5a,  M.musculus
phosphodiesterase 5A, cGMP-specific
865 aa
Pde5a,  R.norvegicus
phosphodiesterase 5A, cGMP-specific
833 aa
PDE5A,  G.gallus
phosphodiesterase 5A, cGMP-specific
856 aa
pde5a,  X.tropicalis
phosphodiesterase 5a, cGMP-specific
821 aa
pde5ab,  D.rerio
phosphodiesterase 5A, cGMP-specific, b
867 aa
Pde11,  D.melanogaster
Phosphodiesterase 11
1161 aa
AgaP_AGAP008646,  A.gambiae
1016 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Crystal structure of the GAF-B domain from human phosphodiesterase 5.
Russwurm M, et al. Proteins 79, 1682-7 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PDEase_I (pfam00233)
  3'5'-cyclic nucleotide phosphodiesterase.
HDc (cl00076)
  Metal dependent phosphohydrolases with conserved 'HD' motif.
HDc (cl17215)
  Metal dependent phosphohydrolases with conserved 'HD' motif.
GAF (cl17456)
  This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pde5a includes H.sapiens PDE5A and R.norvegicus Pde5a.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)

Anthozoa - anthozoans (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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