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HomoloGene:4250. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RASGRP2,  H.sapiens
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
609 aa
RASGRP2,  P.troglodytes
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
609 aa
RASGRP2,  M.mulatta
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
609 aa
RASGRP2,  C.lupus
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
606 aa
RASGRP2,  B.taurus
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
608 aa
Rasgrp2,  M.musculus
RAS, guanyl releasing protein 2
608 aa
Rasgrp2,  R.norvegicus
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
608 aa
LOC101733706,  X.tropicalis
RAS guanyl-releasing protein 2-A-like
594 aa
rasgrp2,  D.rerio
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
592 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
Stefanini L, et al. Blood 114, 2506-14 (2009).
Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.
Subramanian H, et al. J Thromb Haemost 11, 1574-82 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EF-hand_7 (pfam13499)
  EF-hand domain pair.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
RasGEF (cl02485)
  Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
REM (cl02520)
  Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rasgrp2 includes H.sapiens RASGRP2 and R.norvegicus Rasgrp2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)




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