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HomoloGene:2614. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AXIN1,  H.sapiens
axin 1
NP_003493.1
862 aa
AXIN1,  P.troglodytes
axin 1
XP_001152990.3
909 aa
AXIN1,  M.mulatta
axin 1
XP_002802391.1
849 aa
AXIN1,  C.lupus
axin 1
XP_852321.3
920 aa
AXIN1,  B.taurus
axin 1
NP_001178327.1
830 aa
Axin1,  M.musculus
axin 1
NP_033863.2
868 aa
Axin1,  R.norvegicus
axin 1
NP_077381.1
832 aa
AXIN1,  G.gallus
axin 1
NP_990275.1
841 aa
axin1,  X.tropicalis
axin 1
XP_002935881.1
877 aa
axin1,  D.rerio
axin 1
NP_571578.2
835 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hepatocellular carcinoma, somatic.
Caudal duplication anomaly.



Publications
Articles associated with genes and sequences of this homology group.

Conditional disruption of Axin1 leads to development of liver tumors in mice.
Feng GJ, et al. Gastroenterology 143, 1650-9 (2012).
AXIN-1 protein expression and localization in glioblastoma.
Pećina-Slaus N, et al. Coll Antropol 35 Suppl 1, 101-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF1466 (pfam07326)
  Protein of unknown function (DUF1466).
DIX (pfam00778)
  DIX domain.
Axin_TNKS_binding (cd11582)
  Tankyrase binding N-terminal segment of axin.
Axin_b-cat_bind (pfam08833)
  Axin beta-catenin binding domain.
Axin_b-cat_bind (pfam08833)
  Axin beta-catenin binding domain.
DIX (cl02426)
  DIX domain.
RGS (cl02565)
  Regulator of G protein signaling (RGS) domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Axin1 includes H.sapiens AXIN1 and R.norvegicus Axin1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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