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HomoloGene:3561. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ARHGEF6,  H.sapiens
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
776 aa
ARHGEF6,  P.troglodytes
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
748 aa
ARHGEF6,  M.mulatta
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
776 aa
ARHGEF6,  C.lupus
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
799 aa
ARHGEF6,  B.taurus
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
776 aa
Arhgef6,  M.musculus
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
795 aa
Arhgef6,  R.norvegicus
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
772 aa
ARHGEF6,  G.gallus
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
764 aa
arhgef6,  X.tropicalis
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
799 aa
LOC558288,  D.rerio
rho guanine nucleotide exchange factor 6-like
766 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Mental retardation, X-linked nonspecific, type 46.

Articles associated with genes and sequences of this homology group.

The mouse Arhgef6 gene: cDNA sequence, expression analysis, and chromosome assignment.
Kutsche K & Gal A. Cytogenet Cell Genet 95, 196-201 (2001).
alpha Pix enhances mutant huntingtin aggregation.
Eriguchi M, et al. J Neurol Sci 290, 80-5 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF904 (cl11531)
  Protein of unknown function (DUF904).
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
GrpE (cl03075)
  GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arhgef6 includes H.sapiens ARHGEF6 and R.norvegicus Arhgef6.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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