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HomoloGene:515. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

IGF1,  H.sapiens
insulin-like growth factor 1 (somatomedin C)
153 aa
IGF1,  P.troglodytes
insulin-like growth factor 1 (somatomedin C)
153 aa
IGF1,  M.mulatta
insulin-like growth factor 1 (somatomedin C)
153 aa
IGF1,  C.lupus
insulin-like growth factor 1 (somatomedin C)
153 aa
IGF1,  B.taurus
insulin-like growth factor 1 (somatomedin C)
154 aa
Igf1,  M.musculus
insulin-like growth factor 1
153 aa
Igf1,  R.norvegicus
insulin-like growth factor 1
153 aa
IGF1,  G.gallus
insulin-like growth factor 1 (somatomedin C)
153 aa
LOC100486334,  X.tropicalis
insulin-like growth factor I-A-like
153 aa
igf1,  D.rerio
insulin-like growth factor 1
161 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Growth retardation with deafness and mental retardation due to IGF1 deficiency.

Articles associated with genes and sequences of this homology group.

Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling.
Sivaramakrishnan M, et al. Biochim Biophys Acta 1833, 3176-3185 (2013).
Final height and IGF1 in adult survivors of Wilms tumour.
Blijdorp K, et al. Eur J Endocrinol 169, 445-51 (2013).
Can IGF-I polymorphism affect power and endurance athletic performance?
Ben-Zaken S, et al. Growth Horm IGF Res 23, 175-8 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IlGF_like (cl02453)
  Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Igf1 includes H.sapiens IGF1 and R.norvegicus Igf1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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