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HomoloGene:1736. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LIG4,  H.sapiens
ligase IV, DNA, ATP-dependent
NP_001091738.1
911 aa
LIG4,  P.troglodytes
ligase IV, DNA, ATP-dependent
XP_003314254.1
911 aa
LIG4,  C.lupus
ligase IV, DNA, ATP-dependent
XP_005634152.1
911 aa
LIG4,  B.taurus
ligase IV, DNA, ATP-dependent
NP_001178055.1
911 aa
Lig4,  M.musculus
ligase IV, DNA, ATP-dependent
NP_795927.2
911 aa
Lig4,  R.norvegicus
ligase IV, DNA, ATP-dependent
NP_001099565.1
911 aa
LIG4,  G.gallus
ligase IV, DNA, ATP-dependent
NP_001025987.1
912 aa
lig4,  X.tropicalis
ligase IV, DNA, ATP-dependent
NP_001016981.1
911 aa
lig4,  D.rerio
ligase IV, DNA, ATP-dependent
NP_001096593.1
909 aa
Lig4,  D.melanogaster
Ligase4
NP_572907.1
918 aa
AgaP_AGAP000623,  A.gambiae
AgaP_AGAP000623
XP_310455.4
914 aa
DNL4,  S.cerevisiae
DNL4
NP_014647.1
944 aa
KLLA0D01089g,  K.lactis
KLLA0D01089g
XP_453119.1
907 aa
AGOS_ACR008W,  E.gossypii
AGOS_ACR008W
NP_983411.1
981 aa
lig4,  S.pombe
lig4
NP_587888.2
913 aa
MGG_12899,  M.oryzae
MGG_12899
XP_003712808.1
1001 aa
NCU06264,  N.crassa
NCU06264
XP_962868.1
1046 aa
ATLIG4,  A.thaliana
ATLIG4
NP_568851.2
1219 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Multiple myeloma, resistance to.
LIG4 syndrome.



Publications
Articles associated with genes and sequences of this homology group.

A novel mutation in a family with DNA ligase IV deficiency syndrome.
Unal S, et al. Pediatr Blood Cancer 53, 482-4 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DNA_ligase_IV (pfam11411)
  DNA ligase IV.
BRCT (pfam00533)
  BRCA1 C Terminus (BRCT) domain.
DNA_ligase_A_N (pfam04675)
  DNA ligase N terminus.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
OBF_DNA_ligase_family (cl08424)
  The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases.
Adenylation_DNA_ligase_like (cl12015)
  Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lig4 includes H.sapiens LIG4 and R.norvegicus Lig4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (10 transcripts, 8 species)
Liliopsida - monocots (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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