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HomoloGene:39767. Gene conserved in Saccharomycetaceae Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

EST2,  S.cerevisiae
884 aa
KLLA0C18381g,  K.lactis
861 aa
AGOS_AFR494W,  E.gossypii
853 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Telomerase can act as a template- and RNA-independent terminal transferase.
Lue NF, et al. Proc Natl Acad Sci U S A 102, 9778-83 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RVT_1 (pfam00078)
  Reverse transcriptase (RNA-dependent DNA polymerase).
RT_like (cl02808)
  RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
Telomerase_RBD (cl13446)
  Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.




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