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HomoloGene:2999. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CDKN1B,  H.sapiens
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NP_004055.1
198 aa
CDKN1B,  P.troglodytes
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
XP_522347.3
198 aa
CDKN1B,  M.mulatta
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
XP_001085433.1
198 aa
CDKN1B,  C.lupus
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NP_001002957.1
198 aa
CDKN1B,  B.taurus
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NP_001093816.1
198 aa
Cdkn1b,  M.musculus
cyclin-dependent kinase inhibitor 1B
NP_034005.2
197 aa
Cdkn1b,  R.norvegicus
cyclin-dependent kinase inhibitor 1B
NP_113950.2
197 aa
CDKN1B,  G.gallus
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NP_989587.1
198 aa
cdkn1bb,  D.rerio
cyclin-dependent kinase inhibitor 1Bb
NP_997957.1
179 aa
LOC100534692,  D.rerio
cyclin-dependent kinase inhibitor 1B-like
XP_003201420.1
179 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Multiple endocrine neoplasia, type IV.



Publications
Articles associated with genes and sequences of this homology group.

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.
Francis JM, et al. Nat Genet 45, 1483-6 (2013).
Expression of p27Kip1 protein in gastric carcinoma.
Aoyagi K, et al. Hepatogastroenterology 60, 390-4 (2013).
P27 as a prognostic factor of early cervical carcinoma.
Bouda J, et al. Int J Gynecol Cancer 23, 164-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CDI (pfam02234)
  Cyclin-dependent kinase inhibitor.
CDI (pfam02234)
  Cyclin-dependent kinase inhibitor.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdkn1b includes H.sapiens CDKN1B and R.norvegicus Cdkn1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Aves - birds (3 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

 

 

 

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