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HomoloGene:1648. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IL12B,  H.sapiens
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NP_002178.2
328 aa
IL12B,  P.troglodytes
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
XP_527101.2
328 aa
IL12B,  M.mulatta
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NP_001038190.1
328 aa
IL12B,  C.lupus
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NP_001003292.1
329 aa
IL12B,  B.taurus
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NP_776781.1
327 aa
Il12b,  M.musculus
interleukin 12b
NP_032378.1
335 aa
Il12b,  R.norvegicus
interleukin 12B
NP_072133.1
335 aa
IL12B,  G.gallus
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NP_998736.1
315 aa
il12ba,  D.rerio
interleukin 12Ba
NP_001007109.1
324 aa
il12bb,  D.rerio
interleukin 12B, b
XP_002666092.2
305 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Psoriasis, susceptibility to.
BCG and salmonella infection, disseminated.
Asthma, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Adipocytes modulate the phenotype of human macrophages through secreted lipids.
Klein-Wieringa IR, et al. J Immunol 191, 1356-63 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IL12p40_C (pfam10420)
  Cytokine interleukin-12p40 C-terminus.
IL12p40_C (pfam10420)
  Cytokine interleukin-12p40 C-terminus.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il12b includes H.sapiens IL12B and R.norvegicus Il12b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

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