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HomoloGene:1593. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HTT,  H.sapiens
huntingtin
NP_002102.4
3144 aa
HTT,  P.troglodytes
huntingtin
XP_517080.4
3343 aa
HTT,  C.lupus
huntingtin
XP_536221.2
3130 aa
HTT,  B.taurus
huntingtin
XP_002688476.1
3131 aa
Htt,  M.musculus
huntingtin
NP_034544.1
3120 aa
Htt,  R.norvegicus
huntingtin
NP_077333.2
3120 aa
HTT,  G.gallus
huntingtin
XP_420822.3
3095 aa
htt,  X.tropicalis
huntingtin
NP_001007904.1
1148 aa
htt,  D.rerio
huntingtin
NP_571093.1
3121 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Huntington disease.



Publications
Articles associated with genes and sequences of this homology group.

Clinical and genetic features of Huntington disease in Sri Lanka.
Sumathipala DS, et al. BMC Neurol 13, 191 (2013).
MeCP2: a novel Huntingtin interactor.
McFarland KN, et al. Hum Mol Genet 23, 1036-44 (2014).
HTRF analysis of soluble huntingtin in PHAROS PBMCs.
Moscovitch-Lopatin M, et al. Neurology 81, 1134-40 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3652 (pfam12372)
  Huntingtin protein region.
SWI-SNF_Ssr4 (pfam08549)
  Fungal domain of unknown function (DUF1750).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Htt includes H.sapiens HTT and R.norvegicus Htt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 6 species)
Mammalia - mammals (10 transcripts, 9 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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