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HomoloGene:40713. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GDAP1,  H.sapiens
ganglioside induced differentiation associated protein 1
NP_061845.2
358 aa
GDAP1,  P.troglodytes
ganglioside induced differentiation associated protein 1
XP_519814.2
358 aa
GDAP1,  M.mulatta
ganglioside induced differentiation associated protein 1
XP_001086782.1
358 aa
GDAP1,  C.lupus
ganglioside induced differentiation associated protein 1
XP_544131.2
358 aa
GDAP1,  B.taurus
ganglioside-induced differentiation-associated protein 1
NP_001094692.1
358 aa
Gdap1,  M.musculus
ganglioside-induced differentiation-associated-protein 1
NP_034397.1
358 aa
Gdap1,  R.norvegicus
ganglioside-induced differentiation-associated-protein 1
NP_001101367.1
358 aa
GDAP1,  G.gallus
ganglioside induced differentiation associated protein 1
XP_004939972.1
343 aa
gdap1,  X.tropicalis
ganglioside induced differentiation associated protein 1
XP_002937122.1
350 aa
gdap1,  D.rerio
ganglioside-induced differentiation-associated protein 1
NP_001018511.1
362 aa
CG4623,  D.melanogaster
CG4623
NP_001261437.1
326 aa
AgaP_AGAP006132,  A.gambiae
AgaP_AGAP006132
XP_316195.3
290 aa
AT1G77290,  A.thaliana
AT1G77290
NP_001031292.1
266 aa
Os04g0435500,  O.sativa
Os04g0435500
NP_001052848.1
265 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Charcot-Marie-Tooth disease, mixed axonal and demyelinating type.
Charcot-Marie-Tooth disease, type 4A.
Charcot-Marie-Tooth disease, type 2G.
Charcot-Marie-Tooth disease, type 2K.



Publications
Articles associated with genes and sequences of this homology group.

Mitochondria and peripheral neuropathies.
Vital A & Vital C. J Neuropathol Exp Neurol 71, 1036-46 (2012).
A novel autosomal dominant GDAP1 mutation in an Italian CMT2 family.
Manganelli F, et al. J Peripher Nerv Syst 17, 351-5 (2012).
Dominant GDAP1 mutations cause predominantly mild CMT phenotypes.
Zimoń M, et al. Neurology 77, 540-8 (2011).
Two recessive intermediate Charcot-Marie-Tooth patients with GDAP1 mutations.
Chung KW, et al. J Peripher Nerv Syst 16, 143-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Thioredoxin_like (cl00388)
  Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold.
GST_C_family (cl02776)
  C-terminal, alpha helical domain of the Glutathione S-transferase family.
Thioredoxin_like (cl00388)
  Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold.
GST_C_family (cl02776)
  C-terminal, alpha helical domain of the Glutathione S-transferase family.
NADH-u_ox-rdase (cl11377)
  NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gdap1 includes H.sapiens GDAP1 and R.norvegicus Gdap1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (20 transcripts, 19 species)
Liliopsida - monocots (7 transcripts, 7 species)
Coniferopsida - conifers (1 transcript, 1 species)

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)

 

 

 

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