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HomoloGene:32301. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FAM8A1,  H.sapiens
family with sequence similarity 8, member A1
NP_057339.1
413 aa
FAM8A1,  P.troglodytes
family with sequence similarity 8, member A1
XP_527239.2
409 aa
FAM8A1,  M.mulatta
family with sequence similarity 8, member A1
XP_001095672.1
413 aa
FAM8A1,  C.lupus
family with sequence similarity 8, member A1
XP_853088.2
392 aa
FAM8A1,  B.taurus
family with sequence similarity 8, member A1
NP_001075187.1
421 aa
C78339,  M.musculus
expressed sequence C78339
NP_001028364.1
399 aa
Fam8a1,  R.norvegicus
family with sequence similarity 8, member A1
XP_214446.4
384 aa
FAM8A1,  G.gallus
family with sequence similarity 8, member A1
XP_001234653.3
485 aa
fam8a1,  X.tropicalis
family with sequence similarity 8, member A1
XP_002932737.1
287 aa
fam8a1,  D.rerio
family with sequence similarity 8, member A1
NP_001017551.1
326 aa
si:ch73-136l23.1,  D.rerio
si:ch73-136l23.1
XP_692277.6
292 aa
LOC100537042,  D.rerio
protein FAM8A1-like
XP_003200666.1
290 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Defining human ERAD networks through an integrative mapping strategy.
Christianson JC, et al. Nat Cell Biol 14, 93-105 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RDD (pfam06271)
  RDD family.
RDD (cl00746)
  This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus C78339 includes H.sapiens FAM8A1 and R.norvegicus Fam8a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 6 species)
Mammalia - mammals (7 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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