Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:2354. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SPTBN1,  H.sapiens
spectrin, beta, non-erythrocytic 1
NP_003119.2
2364 aa
SPTBN1,  P.troglodytes
spectrin, beta, non-erythrocytic 1
XP_001154155.1
2364 aa
SPTBN1,  M.mulatta
spectrin, beta, non-erythrocytic 1
XP_001114804.1
2364 aa
SPTBN1,  C.lupus
spectrin, beta, non-erythrocytic 1
XP_531827.2
2364 aa
SPTBN1,  B.taurus
spectrin, beta, non-erythrocytic 1
NP_001179205.1
2363 aa
Sptbn1,  M.musculus
spectrin beta, non-erythrocytic 1
NP_787030.2
2363 aa
Sptbn1,  R.norvegicus
spectrin, beta, non-erythrocytic 1
NP_001013148.1
2358 aa
SPTBN1,  G.gallus
spectrin, beta, non-erythrocytic 1
NP_001186354.1
2362 aa
sptb,  D.rerio
spectrin, beta, erythrocytic
NP_571600.1
2357 aa
beta-Spec,  D.melanogaster
beta Spectrin
NP_001259660.1
2308 aa
AgaP_AGAP010895,  A.gambiae
AgaP_AGAP010895
XP_309796.2
2301 aa
unc-70,  C.elegans
unc-70
NP_001024053.1
2302 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Axons break in animals lacking beta-spectrin.
Hammarlund M, et al. J Cell Biol 176, 269-75 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
Spectrin (pfam00435)
  Spectrin repeat.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Spectrin (cl02488)
  Spectrin repeat.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sptbn1 includes H.sapiens SPTBN1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (43 transcripts, 10 species)
Mammalia - mammals (26 transcripts, 14 species)
Amphibia - amphibians (9 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 11 species)
Maxillopoda - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Support Center