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HomoloGene

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HomoloGene:3192. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	BCR, H.sapiens breakpoint cluster region			NP_004318.3 1271 aa
	BCR, P.troglodytes breakpoint cluster region			XP_003317181.1 1202 aa
	BCR, M.mulatta breakpoint cluster region			XP_002798337.1 1148 aa
	BCR, C.lupus breakpoint cluster region			XP_848654.2 1277 aa
	Bcr, M.musculus breakpoint cluster region			NP_001074881.1 1270 aa
	Bcr, R.norvegicus breakpoint cluster region			XP_228091.6 1270 aa
	BCR, G.gallus breakpoint cluster region			XP_415244.3 1351 aa
	bcr, X.tropicalis breakpoint cluster region			NP_001123792.1 1162 aa
	bcr, D.rerio breakpoint cluster region			XP_005161278.1 1315 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:151410 Leukemia, acute lymphocytic.
MIM:608232 Leukemia, chronic myeloid.

Publications Articles associated with genes and sequences of this homology group.
Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice. Nieborowska-Skorska M, et al. Leukemia 27, 2253-4 (2013).
Distribution of genomic breakpoints in chronic myeloid leukemia: analysis of 308 patients. Ross DM, et al. Leukemia 27, 2105-7 (2013).
Tolerant anti-insulin B cells are effective APCs. Kendall PL, et al. J Immunol 190, 2519-26 (2013).
Five most common prognostically important fusion oncogenes are detected in the majority of Pakistani pediatric acute lymphoblastic leukemia patients and are strongly associated with disease biology and treatment outcome. Awan T, et al. Asian Pac J Cancer Prev 13, 5469-75 (2012).
Characteristics and outcomes of patients with V299L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Jabbour E, et al. Blood 120, 3382-3 (2012).
BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability. Slupianek A, et al. Leukemia 27, 629-34 (2013).
Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation. Cortes J, et al. Blood 120, 2573-80 (2012).
MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Giles FJ, et al. Leukemia 27, 113-7 (2013).
Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation. Takahashi N, et al. J Hematol Oncol 5, 23 (2012).
Prevalence and dynamics of bcr-abl kinase domain mutations during imatinib treatment differ in patients with newly diagnosed and recurrent bcr-abl positive acute lymphoblastic leukemia. Pfeifer H, et al. Leukemia 26, 1475-81 (2012).
See all (388)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Bcr-Abl_Oligo (pfam09036) Bcr-Abl oncoprotein oligomerisation domain.
PH-like (cl00273) Pleckstrin homology-like domain.
RhoGAP (cl02570) RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
RhoGEF (cl02571) Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
C2 (cl14603) C2 domain.
PH-like (cl17171) Pleckstrin homology-like domain.
HpaP (cl17849) Type III secretion protein (HpaP).

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:88141 Orthology group for M.musculus Bcr includes H.sapiens BCR and R.norvegicus Bcr.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

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