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HomoloGene:3192. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

BCR,  H.sapiens
breakpoint cluster region
1271 aa
BCR,  P.troglodytes
breakpoint cluster region
1202 aa
BCR,  M.mulatta
breakpoint cluster region
1148 aa
BCR,  C.lupus
breakpoint cluster region
1277 aa
Bcr,  M.musculus
breakpoint cluster region
1270 aa
Bcr,  R.norvegicus
breakpoint cluster region
1270 aa
BCR,  G.gallus
breakpoint cluster region
1351 aa
bcr,  X.tropicalis
breakpoint cluster region
1162 aa
bcr,  D.rerio
breakpoint cluster region
1315 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Leukemia, acute lymphocytic.
Leukemia, chronic myeloid.

Articles associated with genes and sequences of this homology group.

Tolerant anti-insulin B cells are effective APCs.
Kendall PL, et al. J Immunol 190, 2519-26 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Bcr-Abl_Oligo (pfam09036)
  Bcr-Abl oncoprotein oligomerisation domain.
PH-like (cl00273)
  Pleckstrin homology-like domain.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
C2 (cl14603)
  C2 domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
HpaP (cl17849)
  Type III secretion protein (HpaP).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bcr includes H.sapiens BCR and R.norvegicus Bcr.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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