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HomoloGene:23522. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RUFY1,  H.sapiens
RUN and FYVE domain containing 1
708 aa
LOC462328,  P.troglodytes
RUN and FYVE domain-containing protein 1-like
659 aa
RUFY1,  C.lupus
RUN and FYVE domain containing 1
700 aa
RUFY1,  B.taurus
RUN and FYVE domain containing 1
691 aa
Rufy1,  M.musculus
RUN and FYVE domain containing 1
712 aa
Rufy1,  R.norvegicus
RUN and FYVE domain containing 1
711 aa
RUFY1,  G.gallus
RUN and FYVE domain containing 1
692 aa
rufy1,  X.tropicalis
RUN and FYVE domain containing 1
606 aa
LOC100330077,  D.rerio
RUN and FYVE domain-containing protein 1-like
697 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Evolutionarily conserved structural and functional roles of the FYVE domain.
Hayakawa A, et al. Biochem Soc Symp, 95-105 (2007).
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
Boraska V, et al. Am J Med Genet B Neuropsychiatr Genet 159B, 803-11 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FYVE (pfam01363)
  FYVE zinc finger.
RUN (pfam02759)
  RUN domain.
YlqD (pfam11068)
  YlqD protein.
DUF3422 (cl02073)
  Protein of unknown function (DUF3422).
RUN (cl02689)
  RUN domain.
FYVE (cl17764)
  FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1.
DUF3714 (cl19909)
  Protein of unknown function (DUF3714).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rufy1 includes H.sapiens RUFY1 and R.norvegicus Rufy1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (13 transcripts, 8 species)
Mammalia - mammals (10 transcripts, 10 species)
Aves - birds (5 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Trematoda - flatworms (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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