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HomoloGene:1912. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TNFRSF11B,  H.sapiens
tumor necrosis factor receptor superfamily, member 11b
NP_002537.3
401 aa
TNFRSF11B,  P.troglodytes
tumor necrosis factor receptor superfamily, member 11b
XP_519921.2
428 aa
TNFRSF11B,  M.mulatta
tumor necrosis factor receptor superfamily, member 11b
XP_001096915.1
428 aa
TNFRSF11B,  C.lupus
tumor necrosis factor receptor superfamily, member 11b
XP_003639496.1
401 aa
TNFRSF11B,  B.taurus
tumor necrosis factor receptor superfamily, member 11b
NP_001091525.1
402 aa
Tnfrsf11b,  M.musculus
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
NP_032790.3
401 aa
Tnfrsf11b,  R.norvegicus
tumor necrosis factor receptor superfamily, member 11b
NP_037002.1
401 aa
TNFRSF11B,  G.gallus
tumor necrosis factor receptor superfamily, member 11b
NP_001028813.1
402 aa
tnfrsf11b,  X.tropicalis
tumor necrosis factor receptor superfamily, member 11b
XP_002938025.2
378 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Paget disease, juvenile.



Publications
Articles associated with genes and sequences of this homology group.

Mechanistic study of the proangiogenic effect of osteoprotegerin.
Benslimane-Ahmim Z, et al. Angiogenesis 16, 575-93 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Death (pfam00531)
  Death domain.
TNFR (cd00185)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
TNFR (cl12111)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnfrsf11b includes H.sapiens TNFRSF11B and R.norvegicus Tnfrsf11b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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