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HomoloGene:20327. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CA12,  H.sapiens
carbonic anhydrase XII
NP_001209.1
354 aa
CA12,  P.troglodytes
carbonic anhydrase XII
XP_001173904.1
354 aa
CA12,  M.mulatta
carbonic anhydrase XII
XP_001105437.1
354 aa
CA12,  C.lupus
carbonic anhydrase XII
XP_535507.4
406 aa
CA12,  B.taurus
carbonic anhydrase XII
XP_005211801.1
355 aa
Car12,  M.musculus
carbonic anyhydrase 12
NP_848483.3
354 aa
Car12,  R.norvegicus
carbonic anyhydrase 12
NP_001074225.1
354 aa
CA12,  G.gallus
carbonic anhydrase XII
XP_413756.3
347 aa
ca12,  X.tropicalis
carbonic anhydrase XII
NP_001016431.1
335 aa
LOC100537787,  D.rerio
carbonic anhydrase 12-like
XP_005163191.1
350 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperchlorhidrosis, isolated.



Publications
Articles associated with genes and sequences of this homology group.

CAXII Is a sero-diagnostic marker for lung cancer.
Kobayashi M, et al. PLoS One 7, e33952 (2012).
Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues.
Halmi P, et al. Anat Rec A Discov Mol Cell Evol Biol 277, 171-7 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
alpha_CA (cl00012)
  Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
alpha_CA (cl00012)
  Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Car12 includes H.sapiens CA12 and R.norvegicus Car12.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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