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HomoloGene:8059. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ORC4,  H.sapiens
origin recognition complex, subunit 4
NP_002543.2
436 aa
ORC4,  P.troglodytes
origin recognition complex, subunit 4
XP_001159493.1
436 aa
ORC4,  C.lupus
origin recognition complex, subunit 4
XP_533348.2
436 aa
ORC4,  B.taurus
origin recognition complex, subunit 4
NP_001039766.1
436 aa
Orc4,  M.musculus
origin recognition complex, subunit 4
NP_036088.3
433 aa
Orc4,  R.norvegicus
origin recognition complex, subunit 4
NP_954523.1
434 aa
ORC4,  G.gallus
origin recognition complex, subunit 4
XP_004943072.1
494 aa
orc4,  X.tropicalis
origin recognition complex, subunit 4
NP_001005654.1
432 aa
orc4,  D.rerio
origin recognition complex, subunit 4
NP_998348.1
432 aa
Orc4,  D.melanogaster
Origin recognition complex subunit 4
NP_477320.1
459 aa
AgaP_AGAP007063,  A.gambiae
AgaP_AGAP007063
XP_308701.2
459 aa
orc4,  S.pombe
orc4
NP_595825.1
972 aa
ORC4,  A.thaliana
ORC4
NP_178222.4
418 aa
Os01g0683400,  O.sativa
Os01g0683400
NP_001043888.1
470 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Novel ORC4L gene mutation in B-cell lymphoproliferative disorders.
Radojkovic M, et al. Am J Med Sci 338, 527-9 (2009).
Human initiation protein Orc4 prefers triple stranded DNA.
Kusic J, et al. Mol Biol Rep 37, 2317-22 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AAA_16 (pfam13191)
  AAA ATPase domain.
CDC6 (COG1474)
  Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones].
ORC4_C (pfam14629)
  Origin recognition complex (ORC) subunit 4 C-terminus.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Orc4 includes H.sapiens ORC4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 14 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (10 transcripts, 8 species)
Liliopsida - monocots (6 transcripts, 6 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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