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HomoloGene:510. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IGF2,  H.sapiens
insulin-like growth factor 2 (somatomedin A)
NP_001121070.1
236 aa
IGF2,  P.troglodytes
insulin-like growth factor 2 (somatomedin A)
XP_001153640.3
247 aa
LOC721120,  M.mulatta
insulin-like growth factor II-like
XP_002799486.1
75 aa
IGF2,  C.lupus
insulin-like growth factor 2 (somatomedin A)
NP_001182755.1
187 aa
IGF2,  B.taurus
insulin-like growth factor 2 (somatomedin A)
NP_776512.2
179 aa
Igf2,  M.musculus
insulin-like growth factor 2
NP_034644.2
191 aa
Igf2,  R.norvegicus
insulin-like growth factor 2
NP_113699.2
191 aa
IGF2,  G.gallus
insulin-like growth factor 2 (somatomedin A)
NP_001025513.1
187 aa
igf2,  X.tropicalis
insulin-like growth factor 2 (somatomedin A)
NP_001107144.1
182 aa
igf2b,  D.rerio
insulin-like growth factor 2b
NP_001001815.1
212 aa
igf2a,  D.rerio
insulin-like growth factor 2a
NP_571508.1
197 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Intrauterine and postnatal growth retardation.



Publications
Articles associated with genes and sequences of this homology group.

Altered methylation of IGF2 DMR0 is associated with neural tube defects.
Wu L, et al. Mol Cell Biochem 380, 33-42 (2013).
IGF2 increases de novo steroidogenesis in prostate cancer cells.
Lubik AA, et al. Endocr Relat Cancer 20, 173-86 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGF2_C (pfam08365)
  Insulin-like growth factor II E-peptide.
nt_trans (cl00015)
  nucleotidyl transferase superfamily.
IlGF_like (cl02453)
  Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Igf2 includes H.sapiens IGF2 and R.norvegicus Igf2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 14 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Aves - birds (3 transcripts, 3 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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