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HomoloGene:7515. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

REPS1,  H.sapiens
RALBP1 associated Eps domain containing 1
796 aa
REPS1,  P.troglodytes
RALBP1 associated Eps domain containing 1
795 aa
REPS1,  M.mulatta
RALBP1 associated Eps domain containing 1
796 aa
REPS1,  C.lupus
RALBP1 associated Eps domain containing 1
744 aa
REPS1,  B.taurus
RALBP1 associated Eps domain containing 1
794 aa
Reps1,  M.musculus
RalBP1 associated Eps domain containing protein
795 aa
REPS1,  G.gallus
RALBP1 associated Eps domain containing 1
773 aa
reps1,  D.rerio
RALBP1 associated Eps domain containing 1
790 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

RALBP1/RLIP76 mediates multidrug resistance.
Drake KJ, et al. Int J Oncol 30, 139-44 (2007).
Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer.
Singhal SS, et al. Int J Oncol 30, 717-25 (2007).
Cloning, expression and characterization of a novel human REPS1 gene.
Xu J, et al. Biochim Biophys Acta 1522, 118-21 (2001).
Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
Dergai O, et al. Biochem Biophys Res Commun 402, 408-13 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EH (smart00027)
  Eps15 homology domain.
EH (cd00052)
  Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
S-100 (cl08302)
  S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
EFh (cl17302)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Reps1 includes H.sapiens REPS1 and R.norvegicus Reps1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Insecta - insects (6 transcripts, 6 species)

Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)




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