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HomoloGene:2308. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SMARCA2,  H.sapiens
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_001276325.1
1590 aa
SMARCA2,  P.troglodytes
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
XP_003951484.1
1500 aa
SMARCA2,  C.lupus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
XP_850159.1
1574 aa
SMARCA2,  B.taurus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_001092585.1
1554 aa
Smarca2,  M.musculus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_035546.2
1583 aa
Smarca2,  R.norvegicus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_001004446.1
1597 aa
SMARCA2,  G.gallus
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_990470.1
1568 aa
smarca2,  X.tropicalis
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
XP_004910846.1
1572 aa
smarca2,  D.rerio
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NP_001038240.1
1568 aa
brm,  D.melanogaster
brahma
NP_730089.1
1638 aa
AgaP_AGAP010462,  A.gambiae
AgaP_AGAP010462
XP_311484.3
1529 aa
swsn-4,  C.elegans
swsn-4
NP_502082.1
1474 aa
STH1,  S.cerevisiae
STH1
NP_012140.1
1359 aa
KLLA0F04521g,  K.lactis
KLLA0F04521g
XP_455284.1
1344 aa
AGOS_AER375C,  E.gossypii
AGOS_AER375C
NP_985231.1
1288 aa
snf22,  S.pombe
snf22
NP_588472.2
1680 aa
snf21,  S.pombe
snf21
NP_594861.1
1199 aa
MGG_06388,  M.oryzae
MGG_06388
XP_003717185.1
1454 aa
NCU06488,  N.crassa
NCU06488
XP_957128.1
1455 aa
AT5G19310,  A.thaliana
AT5G19310
NP_197432.2
1064 aa
ATCHR12,  A.thaliana
ATCHR12
NP_187252.2
1102 aa
Os05g0144300,  O.sativa
Os05g0144300
NP_001054624.1
1128 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Identified as dominant suppressor of Pc and Pcl alleles. Mutants cause recessive embryonic lethal with strong maternal contribution. Maternal effect lethality is non-rescuable even by two wild-type zygotic alleles.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Identifying targets for the restoration and reactivation of BRM.
Kahali B, et al. Oncogene 33, 653-64 (2014).
The absence of Brm exacerbates photocarcinogenesis.
Halliday GM, et al. Exp Dermatol 21, 599-604 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA02934 (PHA02934)
  Hypothetical protein; Provisional.
BRK (pfam07533)
  BRK domain.
COG5076 (COG5076)
  Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription].
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
SnAC (pfam14619)
  Snf2-ATP coupling, chromatin remodelling complex.
Pro-rich (pfam15240)
  Proline-rich.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
HSA (cl02676)
  This domain is predicted to bind DNA and is often found associated with helicases.
BRK (cl02688)
  BRK domain.
QLQ (cl07469)
  The QLQ domain is named after the conserved Gln, Leu, Gln motif. The QLQ domain is found at the N-terminus of SWI2/SNF2 protein, which has been shown to be involved in protein-protein interactions. This domain has thus been postulated to be involved in mediating protein interactions.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smarca2 includes H.sapiens SMARCA2 and R.norvegicus Smarca2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (29 transcripts, 16 species)
Actinopterygii - bony fishes (21 transcripts, 10 species)
Amphibia - amphibians (4 transcripts, 2 species)
Amniota - vertebrates (3 transcripts, 1 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (4 transcripts, 4 species)
Liliopsida - monocots (2 transcripts, 2 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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