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HomoloGene:132. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GCH1,  H.sapiens
GTP cyclohydrolase 1
NP_000152.1
250 aa
GCH1,  P.troglodytes
GTP cyclohydrolase 1
XP_001161622.1
250 aa
GCH1,  M.mulatta
GTP cyclohydrolase 1
XP_001087365.1
250 aa
GCH1,  C.lupus
GTP cyclohydrolase 1
XP_005623474.1
249 aa
GCH1,  B.taurus
GTP cyclohydrolase 1
XP_002690995.1
249 aa
Gch1,  M.musculus
GTP cyclohydrolase 1
NP_032128.1
241 aa
Gch1,  R.norvegicus
GTP cyclohydrolase 1
NP_077332.1
241 aa
GCH1,  G.gallus
GTP cyclohydrolase 1
NP_990554.1
236 aa
gch1,  X.tropicalis
GTP cyclohydrolase 1
NP_001006789.1
247 aa
gch1,  D.rerio
GTP cyclohydrolase 1
NP_001129727.2
251 aa
Pu,  D.melanogaster
Punch
NP_726038.1
324 aa
AgaP_AGAP006441,  A.gambiae
AgaP_AGAP006441
XP_316477.4
340 aa
cat-4,  C.elegans
cat-4
NP_505710.1
223 aa
FOL2,  S.cerevisiae
FOL2
NP_011783.1
243 aa
KLLA0A09735g,  K.lactis
KLLA0A09735g
XP_451425.1
245 aa
AGOS_AGR335C,  E.gossypii
AGOS_AGR335C
NP_987001.1
243 aa
SPAC17A5.13,  S.pombe
SPAC17A5.13
NP_593481.1
235 aa
MGG_09458,  M.oryzae
MGG_09458
XP_003712296.1
310 aa
NCU07774,  N.crassa
NCU07774
XP_958695.2
182 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The structural gene for guanosine triphosphate 7,8-8,9-dehydrolase = GTP cyclohydrolase (GTP CH) which catalyzes the first step in pteridine biosynthesis, the conversion of GTP to dihydroneopterin with the release of formic acid; GTP CH activity proportional to the number of Pu+ alleles. Purification and characterization by Weisberg and O'Donnell (1986); the active complex has an apparent molecular mass of 575,000 daltons comprized of 39,000-dalton subunits. Developmentally regulated with a short-lived activity peak at or shortly before eclosion; 80-90% of activity found in the head; activity not detectable in embryos. (See FlyBase for complete description.)

H.sapiens
Dystonia, DOPA-responsive.
Phenylketonuria, atypical, due to GCH1 deficiency.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HCV_capsid (pfam01543)
  Hepatitis C virus capsid protein.
TFold (cl00263)
  Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gch1 includes H.sapiens GCH1 and R.norvegicus Gch1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 9 species)
Mammalia - mammals (10 transcripts, 10 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (29 transcripts, 20 species)
Liliopsida - monocots (14 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Pezizomycetes - ascomycetes (2 transcripts, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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