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HomoloGene:2063. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MAP2K1,  H.sapiens
mitogen-activated protein kinase kinase 1
NP_002746.1
393 aa
MAP2K1,  P.troglodytes
mitogen-activated protein kinase kinase 1
NP_001009071.1
393 aa
MAP2K1,  M.mulatta
mitogen-activated protein kinase kinase 1
XP_001110225.1
393 aa
MAP2K1,  C.lupus
mitogen-activated protein kinase kinase 1
NP_001041559.1
381 aa
MAP2K1,  B.taurus
mitogen-activated protein kinase kinase 1
NP_001124224.1
393 aa
Map2k1,  M.musculus
mitogen-activated protein kinase kinase 1
NP_032953.1
393 aa
Map2k1,  R.norvegicus
mitogen activated protein kinase kinase 1
NP_113831.1
393 aa
MAP2K1,  G.gallus
mitogen-activated protein kinase kinase 1
NP_001005830.1
395 aa
map2k1,  X.tropicalis
mitogen-activated protein kinase kinase 1
NP_001008058.1
395 aa
map2k1,  D.rerio
mitogen-activated protein kinase kinase 1
NP_998584.2
395 aa
Dsor1,  D.melanogaster
Downstream of raf1
NP_511098.1
396 aa
AgaP_AGAP001103,  A.gambiae
AgaP_AGAP001103
XP_322064.4
406 aa
mek-2,  C.elegans
mek-2
NP_491087.1
387 aa
byr1,  S.pombe
byr1
NP_593026.1
340 aa
MGG_00800,  M.oryzae
MGG_00800
XP_003718185.1
415 aa
NCU04612,  N.crassa
NCU04612
XP_958855.1
511 aa
MEK1,  A.thaliana
MEK1
NP_974619.1
354 aa
MKK2,  A.thaliana
MKK2
NP_194710.1
363 aa
Os06g0147800,  O.sativa
Os06g0147800
NP_001056806.1
352 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiofaciocutaneous syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Oncogenic MAP2K1 mutations in human epithelial tumors.
Choi YL, et al. Carcinogenesis 33, 956-61 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Map2k1 includes H.sapiens MAP2K1 and R.norvegicus Map2k1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (41 transcripts, 31 species)
Liliopsida - monocots (10 transcripts, 8 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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