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HomoloGene:3374. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCO1,  H.sapiens
SCO1 cytochrome c oxidase assembly protein
NP_004580.1
301 aa
SCO1,  P.troglodytes
SCO cytochrome oxidase deficient homolog 1 (yeast)
XP_001164786.1
301 aa
LOC722074,  M.mulatta
protein SCO1 homolog, mitochondrial-like
XP_001118271.1
301 aa
SCO1,  C.lupus
SCO cytochrome oxidase deficient homolog 1 (yeast)
XP_546624.3
304 aa
SCO1,  B.taurus
SCO cytochrome oxidase deficient homolog 1 (yeast)
NP_001073712.1
305 aa
Sco1,  M.musculus
SCO cytochrome oxidase deficient homolog 1 (yeast)
NP_001035115.1
284 aa
Sco1,  R.norvegicus
SCO1 cytochrome c oxidase assembly protein
NP_001166845.1
284 aa
SCO1,  G.gallus
SCO cytochrome oxidase deficient homolog 1 (yeast)
XP_004946120.1
182 aa
LOC100494754,  X.tropicalis
protein SCO1 homolog, mitochondrial-like
XP_002937049.2
250 aa
LOC796572,  D.rerio
protein SCO1 homolog, mitochondrial-like
XP_005164365.1
318 aa
Scox,  D.melanogaster
Synthesis of cytochrome c oxidase
NP_608884.1
251 aa
AgaP_AGAP008774,  A.gambiae
AgaP_AGAP008774
XP_314900.3
276 aa
sco-1,  C.elegans
sco-1
NP_494755.1
312 aa
SCO1,  S.cerevisiae
SCO1
NP_009593.1
295 aa
KLLA0D03630g,  K.lactis
KLLA0D03630g
XP_453226.1
312 aa
AGOS_AEL191C,  E.gossypii
AGOS_AEL191C
NP_984670.2
294 aa
sco1,  S.pombe
sco1
NP_595287.1
263 aa
MGG_03006,  M.oryzae
MGG_03006
XP_003720686.1
294 aa
NCU03177,  N.crassa
NCU03177
XP_964583.2
290 aa
AT3G08950,  A.thaliana
AT3G08950
NP_566339.1
334 aa
Os02g0159700,  O.sativa
Os02g0159700
NP_001045964.1
197 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hepatic failure, early onset, and neurologic disorder.



Publications
Articles associated with genes and sequences of this homology group.

A hint for the function of human Sco1 from different structures.
Banci L, et al. Proc Natl Acad Sci U S A 103, 8595-600 (2006).
Crystal structure of yeast Sco1.
Abajian C & Rosenzweig AC. J Biol Inorg Chem 11, 459-66 (2006).
Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer.
Banci L, et al. Proc Natl Acad Sci U S A 105, 6803-8 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Thioredoxin_like (cl00388)
  Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sco1 includes H.sapiens SCO1 and R.norvegicus Sco1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Ascidiacea - tunicates (5 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (26 transcripts, 22 species)
Liliopsida - monocots (8 transcripts, 7 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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