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HomoloGene:129835. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYH9,  H.sapiens
myosin, heavy chain 9, non-muscle
NP_002464.1
1960 aa
MYH9,  P.troglodytes
myosin, heavy chain 9, non-muscle
XP_003953928.1
1872 aa
MYH9,  C.lupus
myosin, heavy chain 9, non-muscle
NP_001104237.1
1960 aa
MYH9,  B.taurus
myosin, heavy chain 9, non-muscle
NP_001179691.1
1965 aa
Myh9,  M.musculus
myosin, heavy polypeptide 9, non-muscle
NP_071855.2
1960 aa
LOC100911597,  R.norvegicus
myosin-9-like
XP_003750426.1
1960 aa
MYH9,  G.gallus
myosin, heavy chain 9, non-muscle
NP_990808.1
1959 aa
myh9,  X.tropicalis
myosin, heavy chain 9, non-muscle
XP_002934764.2
1960 aa
myh9a,  D.rerio
myosin, heavy polypeptide 9a, non-muscle
NP_001091647.2
1961 aa
myp2,  S.pombe
myp2
NP_593816.1
2104 aa
MGG_03060,  M.oryzae
MGG_03060
XP_003720621.1
2409 aa
NCU00551,  N.crassa
NCU00551
XP_964712.2
2401 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Fechtner syndrome.
Epstein syndrome.
May-Hegglin anomaly.
Macrothrombocytopenia and progressive sensorineural deafness.
Deafness, autosomal dominant 17.
Sebastian syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Epistatic role of the MYH9/APOL1 region on familial hematuria genes.
Voskarides K, et al. PLoS One 8, e57925 (2013).
Familial cases with MYH9 disorders caused by MYH9 S96L mutation.
Murayama S, et al. Pediatr Int 55, 102-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
phage_LysB (TIGR03495)
  phage lysis regulatory protein, LysB family.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
DUF2869 (pfam11068)
  Protein of unknown function (DUF2869).
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
RRF (cl00240)
  Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another ...
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
Birna_RdRp (pfam04197)
  Birnavirus RNA dependent RNA polymerase (VP1).
Taxilin (pfam09728)
  Myosin-like coiled-coil protein.
RRF (cl00240)
  Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another ...
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myh9 includes H.sapiens MYH9 and R.norvegicus Myh9.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 10 species)
Actinopterygii - bony fishes (17 transcripts, 8 species)
Amphibia - amphibians (5 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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