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HomoloGene:3557. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

EIF2AK3,  H.sapiens
eukaryotic translation initiation factor 2-alpha kinase 3
NP_004827.4
1116 aa
EIF2AK3,  P.troglodytes
eukaryotic translation initiation factor 2-alpha kinase 3
XP_001140984.1
1115 aa
EIF2AK3,  M.mulatta
eukaryotic translation initiation factor 2-alpha kinase 3
XP_001094493.1
1115 aa
EIF2AK3,  C.lupus
eukaryotic translation initiation factor 2-alpha kinase 3
XP_854775.1
1113 aa
EIF2AK3,  B.taurus
eukaryotic translation initiation factor 2-alpha kinase 3
NP_001091555.1
1115 aa
Eif2ak3,  M.musculus
eukaryotic translation initiation factor 2 alpha kinase 3
NP_034251.2
1114 aa
Eif2ak3,  R.norvegicus
eukaryotic translation initiation factor 2 alpha kinase 3
NP_113787.1
1108 aa
EIF2AK3,  G.gallus
eukaryotic translation initiation factor 2-alpha kinase 3
XP_420868.2
1085 aa
eif2ak3,  X.tropicalis
eukaryotic translation initiation factor 2-alpha kinase 3
XP_002937326.2
1045 aa
eif2ak3,  D.rerio
eukaryotic translation initiation factor 2-alpha kinase 3
XP_005156642.1
1099 aa
AgaP_AGAP013266,  A.gambiae
AgaP_AGAP013266
XP_003436241.1
1140 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Wolcott-Rallison syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Down-regulation of PERK enhances resistance to ionizing radiation.
Oommen D & Prise KM. Biochem Biophys Res Commun 441, 31-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Luminal_IRE1_like (cl14874)
  The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eif2ak3 includes H.sapiens EIF2AK3 and R.norvegicus Eif2ak3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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