Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:76542. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRX,  H.sapiens
periaxin
NP_870998.2
1461 aa
PRX,  P.troglodytes
periaxin
XP_003953543.1
1463 aa
LOC702329,  M.mulatta
periaxin-like
XP_002808239.1
1382 aa
PRX,  C.lupus
periaxin
XP_541615.4
1404 aa
PRX,  B.taurus
periaxin
XP_003587302.2
1349 aa
Prx,  M.musculus
periaxin
NP_932165.2
1391 aa
Prx,  R.norvegicus
periaxin
NP_076466.2
1383 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Charcot-Marie-Tooth neuoropathy 4F.
Dejerine-Sottas neuropathy, autosomal recessive.



Publications
Articles associated with genes and sequences of this homology group.

Late-onset Charcot-Marie-Tooth disease 4F caused by periaxin gene mutation.
Tokunaga S, et al. Neurogenetics 13, 359-65 (2012).
Periaxin mutations cause a broad spectrum of demyelinating neuropathies.
Takashima H, et al. Ann Neurol 51, 709-15 (2002).
Periaxin mutations cause recessive Dejerine-Sottas neuropathy.
Boerkoel CF, et al. Am J Hum Genet 68, 325-33 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cornifin (pfam02389)
  Cornifin (SPRR) family.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prx includes H.sapiens PRX and R.norvegicus Prx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

Support Center