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HomoloGene:72248. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SIX5,  H.sapiens
SIX homeobox 5
739 aa
SIX5,  P.troglodytes
SIX homeobox 5
709 aa
SIX5,  M.mulatta
SIX homeobox 5
740 aa
SIX5,  C.lupus
SIX homeobox 5
625 aa
SIX5,  B.taurus
SIX homeobox 5
738 aa
Six5,  M.musculus
sine oculis-related homeobox 5
719 aa
Six5,  R.norvegicus
SIX homeobox 5
719 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Branchiootorenal syndrome 2.

Articles associated with genes and sequences of this homology group.

Myotonia and muscle contractile properties in mice with SIX5 deficiency.
Personius KE, et al. Muscle Nerve 31, 503-5 (2005).
Six5 is required for spermatogenic cell survival and spermiogenesis.
Sarkar PS, et al. Hum Mol Genet 13, 1421-31 (2004).
Expression of a homeobox gene (SIX5) in borderline ovarian tumours.
Winchester C, et al. J Clin Pathol 53, 212-7 (2000).
Functional analysis of the homeodomain protein SIX5.
Harris SE, et al. Nucleic Acids Res 28, 1871-8 (2000).
Skeletal muscle Na currents in mice heterozygous for Six5 deficiency.
Mistry DJ, et al. Physiol Genomics 6, 153-8 (2001).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Six5 includes H.sapiens SIX5 and R.norvegicus Six5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 5 species)
Actinopterygii - bony fishes (1 transcript, 1 species)




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