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HomoloGene:48227. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RAD54L,  H.sapiens
RAD54-like (S. cerevisiae)
NP_003570.2
747 aa
RAD54L,  P.troglodytes
RAD54-like (S. cerevisiae)
XP_513146.3
747 aa
RAD54L,  C.lupus
RAD54-like (S. cerevisiae)
XP_532592.3
747 aa
RAD54L,  B.taurus
RAD54-like (S. cerevisiae)
NP_001124238.1
749 aa
Rad54l,  M.musculus
RAD54 like (S. cerevisiae)
NP_033041.3
747 aa
Rad54l,  R.norvegicus
RAD54 like (S. cerevisiae)
NP_001128432.1
748 aa
RAD54L,  G.gallus
RAD54-like (S. cerevisiae)
XP_422447.3
742 aa
rad54l,  X.tropicalis
RAD54-like
NP_001001241.1
742 aa
rad54l,  D.rerio
RAD54-like (S. cerevisiae)
NP_957438.1
738 aa
okr,  D.melanogaster
okra
NP_476661.1
784 aa
AgaP_AGAP008748,  A.gambiae
AgaP_AGAP008748
XP_557901.3
789 aa
rad-54,  C.elegans
rad-54
NP_492438.1
818 aa
RAD54,  S.cerevisiae
RAD54
NP_011352.1
898 aa
KLLA0A03069g,  K.lactis
KLLA0A03069g
XP_451134.1
895 aa
AGOS_AEL297W,  E.gossypii
AGOS_AEL297W
NP_984563.2
895 aa
rhp54,  S.pombe
rhp54
NP_594290.1
852 aa
MGG_03549,  M.oryzae
MGG_03549
XP_003716366.1
803 aa
NCU11255,  N.crassa
NCU11255
XP_959470.1
831 aa
RAD54,  A.thaliana
RAD54
NP_188552.3
910 aa
Os02g0762800,  O.sativa
Os02g0762800
NP_001048207.2
879 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer, invasive intraductal.
Colon adenocarcinoma.
Lymphoma, non-Hodgkin.



Publications
Articles associated with genes and sequences of this homology group.

Rad54 dissociates homologous recombination intermediates by branch migration.
Bugreev DV, et al. Nat Struct Mol Biol 14, 746-53 (2007).
Interactions of human rad54 protein with branched DNA molecules.
Mazina OM, et al. J Biol Chem 282, 21068-80 (2007).
Rad54 protein promotes branch migration of Holliday junctions.
Bugreev DV, et al. Nature 442, 590-3 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
Rad54_N (pfam08658)
  Rad54 N terminal.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
Rad54_N (pfam08658)
  Rad54 N terminal.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rad54l includes H.sapiens RAD54L.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (8 transcripts, 7 species)
Liliopsida - monocots (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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