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HomoloGene:11419. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTRR,  H.sapiens
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NP_076915.2
725 aa
MTRR,  P.troglodytes
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_001145250.1
725 aa
MTRR,  M.mulatta
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_002804366.1
704 aa
MTRR,  C.lupus
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_005639737.1
697 aa
MTRR,  B.taurus
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NP_001025470.1
695 aa
Mtrr,  M.musculus
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NP_766068.1
696 aa
Mtrr,  R.norvegicus
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NP_001034092.1
506 aa
MTRR,  G.gallus
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_004935186.1
693 aa
mtrr,  X.tropicalis
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_002942769.2
695 aa
mtrr,  D.rerio
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
XP_689157.2
697 aa
mtrr-1,  C.elegans
mtrr-1
NP_495978.1
682 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Homocystinuria-megaloblastic anemia, cbl E type.
Neural tube defects, folate-sensitive, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

MTRR 66A>G polymorphism as maternal risk factor for Down syndrome: a meta-analysis.
Amorim MR & Lima MA. Genet Test Mol Biomarkers 17, 69-73 (2013).
MTRR A66G polymorphism and breast cancer risk: a meta-analysis.
Hu J, et al. Breast Cancer Res Treat 124, 779-84 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FMN_red (cl00438)
  NADPH-dependent FMN reductase.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mtrr includes H.sapiens MTRR and R.norvegicus Mtrr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Arthropoda
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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