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HomoloGene:21300. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCN10A,  H.sapiens
sodium channel, voltage-gated, type X, alpha subunit
NP_006505.2
1956 aa
SCN10A,  P.troglodytes
sodium channel, voltage-gated, type X, alpha subunit
XP_516372.3
1959 aa
SCN10A,  M.mulatta
sodium channel protein type 10 subunit alpha-like
XP_002808374.1
1969 aa
SCN10A,  C.lupus
sodium channel, voltage-gated, type X, alpha subunit
NP_001003203.1
1962 aa
SCN10A,  B.taurus
sodium channel, voltage-gated, type X, alpha subunit
XP_002696962.1
1973 aa
Scn10a,  M.musculus
sodium channel, voltage-gated, type X, alpha
NP_001192250.1
1958 aa
Scn10a,  R.norvegicus
sodium channel, voltage-gated, type X, alpha subunit
NP_058943.1
1957 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Gain-of-function Nav1.8 mutations in painful neuropathy.
Faber CG, et al. Proc Natl Acad Sci U S A 109, 19444-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn10a includes H.sapiens SCN10A and R.norvegicus Scn10a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)

 

 

 

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