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HomoloGene:5247. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PNKP,  H.sapiens
polynucleotide kinase 3'-phosphatase
NP_009185.2
521 aa
PNKP,  P.troglodytes
polynucleotide kinase 3'-phosphatase
XP_003316598.1
484 aa
PNKP,  M.mulatta
polynucleotide kinase 3'-phosphatase
XP_001115581.1
521 aa
PNKP,  C.lupus
polynucleotide kinase 3'-phosphatase
XP_541488.2
521 aa
PNKP,  B.taurus
polynucleotide kinase 3'-phosphatase
NP_001076991.1
194 aa
Pnkp,  M.musculus
polynucleotide kinase 3'- phosphatase
NP_067524.2
522 aa
Pnkp,  R.norvegicus
polynucleotide kinase 3'-phosphatase
NP_001004259.1
522 aa
pnkp,  X.tropicalis
polynucleotide kinase 3'-phosphatase
NP_001120633.1
597 aa
pnkp,  D.rerio
polynucleotide kinase 3'-phosphatase
NP_001071046.1
586 aa
CG9601,  D.melanogaster
CG9601
NP_649792.3
523 aa
F21D5.5,  C.elegans
F21D5.5
NP_501503.1
407 aa
pnk1,  S.pombe
pnk1
NP_593635.2
408 aa
MGG_09734,  M.oryzae
MGG_09734
XP_003717618.1
517 aa
NCU08151,  N.crassa
NCU08151
XP_959562.2
484 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microcephaly, seizures, and developmental delaty.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
PNK-3'Pase (TIGR01663)
  polynucleotide 5'-kinase 3'-phosphatase.
HAD_like (cl11391)
  Haloacid Dehalogenase-like Hydrolases.
MatK_N (pfam01824)
  MatK/TrnK amino terminal region.
AAA_17 (pfam13207)
  AAA domain.
AAA_33 (pfam13671)
  AAA domain.
PNK3P (pfam08645)
  Polynucleotide kinase 3 phosphatase.
AAA_33 (pfam13671)
  AAA domain.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
AAA_17 (cl19128)
  AAA domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pnkp includes H.sapiens PNKP and R.norvegicus Pnkp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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