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HomoloGene:20090. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

INSR,  H.sapiens
insulin receptor
NP_000199.2
1382 aa
INSR,  P.troglodytes
insulin receptor
XP_512324.2
773 aa
INSR,  M.mulatta
insulin receptor
XP_001094337.2
1269 aa
INSR,  C.lupus
insulin receptor
XP_005633279.1
1406 aa
INSR,  B.taurus
insulin receptor
XP_002688878.3
1382 aa
Insr,  M.musculus
insulin receptor
NP_034698.2
1372 aa
Insr,  R.norvegicus
insulin receptor
NP_058767.2
1384 aa
INSR,  G.gallus
insulin receptor
XP_001233399.3
1353 aa
LOC100492718,  X.tropicalis
insulin receptor-like
XP_002934425.2
1360 aa
insra,  D.rerio
insulin receptor a
NP_001136144.1
1353 aa
insrb,  D.rerio
insulin receptor b
NP_001116701.1
1348 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leprechaunism.
Rabson-Mendenhall syndrome.
Hyperinsulinemic hypoglycemia, familial, 5.
Diabetes mellitus, insulin-resistant, with acanthosis nigricans.



Publications
Articles associated with genes and sequences of this homology group.

Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.
Tiwari S, et al. J Am Soc Nephrol 24, 1209-14 (2013).
Association of His1085His INSR gene polymorphism with type 2 diabetes in South Indians.
Bodhini D, et al. Diabetes Technol Ther 14, 696-700 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Recep_L_domain (pfam01030)
  Receptor L domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Insr includes H.sapiens INSR and R.norvegicus Insr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (22 transcripts, 11 species)
Actinopterygii - bony fishes (17 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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