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HomoloGene:81940. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ADAMTS10,  H.sapiens
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NP_112219.3
1103 aa
ADAMTS10,  P.troglodytes
ADAM metallopeptidase with thrombospondin type 1 motif, 10
XP_001159753.1
1103 aa
ADAMTS10,  M.mulatta
ADAM metallopeptidase with thrombospondin type 1 motif, 10
XP_001095217.1
1103 aa
ADAMTS10,  C.lupus
ADAM metallopeptidase with thrombospondin type 1 motif, 10
XP_854320.1
1103 aa
ADAMTS10,  B.taurus
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NP_001192679.1
1103 aa
Adamts10,  M.musculus
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
NP_766207.2
1104 aa
Adamts10,  R.norvegicus
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NP_001258374.1
1104 aa
ADAMTS10,  G.gallus
ADAM metallopeptidase with thrombospondin type 1 motif, 10
XP_001232250.1
1109 aa
adamts10,  X.tropicalis
ADAM metallopeptidase with thrombospondin type 1 motif, 10
XP_002938612.2
1105 aa
adamts10,  D.rerio
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NP_001116746.1
1108 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Weill-Marchesani syndrome, recessive.



Publications
Articles associated with genes and sequences of this homology group.

ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome.
Dagoneau N, et al. Am J Hum Genet 75, 801-6 (2004).
Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome.
Faivre L, et al. Am J Med Genet A 123A, 204-7 (2003).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLAC (pfam08686)
  PLAC (protease and lacunin) domain.
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
ADAM_spacer1 (pfam05986)
  ADAM-TS Spacer 1.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
ADAM_spacer1 (pfam05986)
  ADAM-TS Spacer 1.
PLAC (pfam08686)
  PLAC (protease and lacunin) domain.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
TSP_1 (cl15278)
  Thrombospondin type 1 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Adamts10 includes H.sapiens ADAMTS10.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)

 

 

 

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