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HomoloGene:38008. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NUP214,  H.sapiens
nucleoporin 214kDa
NP_005076.3
2090 aa
NUP214,  P.troglodytes
nucleoporin 214kDa
XP_001167010.3
2091 aa
NUP214,  M.mulatta
nucleoporin 214kDa
XP_001118571.2
2139 aa
NUP214,  C.lupus
nucleoporin 214kDa
XP_850680.3
2163 aa
NUP214,  B.taurus
nucleoporin 214kDa
NP_001192372.1
2087 aa
Nup214,  M.musculus
nucleoporin 214
NP_758472.2
2085 aa
Nup214,  R.norvegicus
nucleoporin 214
NP_001162031.1
2067 aa
NUP214,  G.gallus
nucleoporin 214kDa
XP_425333.4
2084 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, T-cell acute lymphoblastic.
Leukemia, acute myeloid.



Publications
Articles associated with genes and sequences of this homology group.

Assessing the value of CAN-gene mutations using MALDI-TOF MS.
Kohler C, et al. J Cancer Res Clin Oncol 137, 1239-44 (2011).
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.
Napetschnig J, et al. Proc Natl Acad Sci U S A 104, 1783-8 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA03255 (PHA03255)
  BDLF3; Provisional.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleoporin_FG (pfam13634)
  Nucleoporin FG repeat region.
DUF4551 (pfam15087)
  Protein of unknown function (DUF4551).
DUF1517 (cl01807)
  Protein of unknown function (DUF1517).
RPE65 (cl10080)
  Retinal pigment epithelial membrane protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nup214 includes H.sapiens NUP214 and R.norvegicus Nup214.


 

 

 

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