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HomoloGene:27006. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PEX1,  H.sapiens
peroxisomal biogenesis factor 1
1283 aa
PEX1,  P.troglodytes
peroxisomal biogenesis factor 1
1283 aa
PEX1,  M.mulatta
peroxisomal biogenesis factor 1
1216 aa
PEX1,  C.lupus
peroxisomal biogenesis factor 1
1267 aa
PEX1,  B.taurus
peroxisomal biogenesis factor 1
1281 aa
Pex1,  M.musculus
peroxisomal biogenesis factor 1
1244 aa
Pex1,  R.norvegicus
peroxisomal biogenesis factor 1
1283 aa
PEX1,  G.gallus
peroxisomal biogenesis factor 1
1291 aa
pex1,  X.tropicalis
peroxisomal biogenesis factor 1
1269 aa
pex1,  D.rerio
peroxisomal biogenesis factor 1
1237 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Adrenoleukodystrophy, neonatal.
Zellweger syndrome-1.
Refsum disease, infantile.

Articles associated with genes and sequences of this homology group.

Novel PEX1 coding mutations and 5' UTR regulatory polymorphisms.
Maxwell MA, et al. Hum Mutat 26, 279 (2005).
Metabolic and molecular basis of peroxisomal disorders: a review.
Wanders RJ. Am J Med Genet A 126A, 355-75 (2004).
Study of mutant proteins with folding defects in cultured patient cells.
Dodt G & Walter C. Methods Mol Biol 232, 165-73 (2003).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PEX-2N (pfam09263)
  Peroxisome biogenesis factor 1, N-terminal.
AAA (pfam00004)
  ATPase family associated with various cellular activities (AAA).
PEX-1N (pfam09262)
  Peroxisome biogenesis factor 1, N-terminal.
SpoVK (COG0464)
  ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].
PEX-1N (pfam09262)
  Peroxisome biogenesis factor 1, N-terminal.
MopB_CT (cl09929)
  Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- ...
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pex1 includes H.sapiens PEX1 and R.norvegicus Pex1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Eudicotyledons - eudicots (2 transcripts, 2 species)
Isoetopsida - club-mosses (1 transcript, 1 species)




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