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HomoloGene:159. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HMGCL,  H.sapiens
3-hydroxymethyl-3-methylglutaryl-CoA lyase
NP_000182.2
325 aa
HMGCL,  P.troglodytes
3-hydroxymethyl-3-methylglutaryl-CoA lyase
XP_001166273.1
325 aa
HMGCL,  M.mulatta
3-hydroxymethyl-3-methylglutaryl-CoA lyase
XP_001104722.2
360 aa
HMGCL,  C.lupus
3-hydroxymethyl-3-methylglutaryl-CoA lyase
XP_003638949.1
325 aa
HMGCL,  B.taurus
3-hydroxymethyl-3-methylglutaryl-CoA lyase
NP_001068600.1
325 aa
Hmgcl,  M.musculus
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
NP_032280.2
325 aa
Hmgcl,  R.norvegicus
3-hydroxymethyl-3-methylglutaryl-CoA lyase
NP_077362.1
325 aa
HMGCL,  G.gallus
3-hydroxymethyl-3-methylglutaryl-CoA lyase
NP_001185643.1
319 aa
LOC100494904,  X.tropicalis
hydroxymethylglutaryl-CoA lyase, mitochondrial-like
XP_002934605.1
331 aa
hmgcl,  D.rerio
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
NP_957509.1
340 aa
CG10399,  D.melanogaster
CG10399
NP_609089.1
323 aa
AgaP_AGAP008717,  A.gambiae
AgaP_AGAP008717
XP_314824.4
303 aa
Y71G12B.10,  C.elegans
Y71G12B.10
NP_490889.1
318 aa
AT2G26800,  A.thaliana
AT2G26800
NP_850087.1
433 aa
Os01g0269000,  O.sativa
Os01g0269000
NP_001042696.1
459 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
HMG-CoA lyase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Molecular genetics of HMG-CoA lyase deficiency.
PiƩ J, et al. Mol Genet Metab 92, 198-209 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DRE_TIM_metallolyase (cl18962)
  DRE-TIM metallolyase superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hmgcl includes H.sapiens HMGCL and R.norvegicus Hmgcl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (47 transcripts, 26 species)
Liliopsida - monocots (17 transcripts, 9 species)
Bryopsida - mosses (3 transcripts, 1 species)
Coniferopsida - conifers (3 transcripts, 3 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (15 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (12 transcripts, 9 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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