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HomoloGene:37424. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SI,  H.sapiens
sucrase-isomaltase (alpha-glucosidase)
1827 aa
SI,  P.troglodytes
sucrase-isomaltase (alpha-glucosidase)
1826 aa
SI,  M.mulatta
sucrase-isomaltase (alpha-glucosidase)
1772 aa
SI,  C.lupus
sucrase-isomaltase (alpha-glucosidase)
1825 aa
SI,  B.taurus
sucrase-isomaltase (alpha-glucosidase)
1812 aa
Sis,  M.musculus
sucrase isomaltase (alpha-glucosidase)
1818 aa
Si,  R.norvegicus
sucrase-isomaltase (alpha-glucosidase)
1841 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Sucrase-isomaltase deficiency, congenital.

Articles associated with genes and sequences of this homology group.

Four mutations in the SI gene are responsible for the majority of clinical symptoms of CSID.
Uhrich S, et al. J Pediatr Gastroenterol Nutr 55 Suppl 2, S34-5 (2012).
Effect of harmaline on rat intestinal brush border sucrase activity.
Kaur N, et al. Indian J Biochem Biophys 39, 119-23 (2002).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Gal_mutarotas_2 (pfam13802)
  Galactose mutarotase-like.
Glyco_hydro_31 (pfam01055)
  Glycosyl hydrolases family 31.
Gal_mutarotas_2 (pfam13802)
  Galactose mutarotase-like.
Trefoil (cl00103)
  P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.
GH31 (cl11402)
  The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sis includes H.sapiens SI.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (4 transcripts, 4 species)

Branchiopoda - crustaceans (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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