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HomoloGene:615. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DBH,  H.sapiens
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NP_000778.3
617 aa
DBH,  P.troglodytes
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
XP_520341.2
617 aa
DBH,  M.mulatta
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
XP_001100196.2
620 aa
DBH,  C.lupus
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NP_001005263.1
625 aa
DBH,  B.taurus
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NP_851338.1
610 aa
Dbh,  M.musculus
dopamine beta hydroxylase
NP_620392.2
622 aa
Dbh,  R.norvegicus
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NP_037290.2
621 aa
DBH,  G.gallus
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
XP_415429.4
632 aa
dbh,  X.tropicalis
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
XP_002942324.2
615 aa
dbh,  D.rerio
dopamine beta hydroxylase
NP_001103164.1
614 aa
Tbh,  D.melanogaster
Tyramine beta hydroxylase
NP_788884.1
670 aa
AgaP_AGAP010485,  A.gambiae
AgaP_AGAP010485
XP_307804.4
604 aa
tbh-1,  C.elegans
tbh-1
NP_001257264.1
657 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease, resistance to.
Dopamine beta-hydroxylase deficiency.
Dopamine-beta-hydroxylase activity levels, plasma.



Publications
Articles associated with genes and sequences of this homology group.

DBH gene as predictor of response in a cocaine vaccine clinical trial.
Kosten TR, et al. Neurosci Lett 541, 29-33 (2013).
Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease.
Mustapic M, et al. Prog Neuropsychopharmacol Biol Psychiatry 44, 94-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cu2_monooxygen (pfam01082)
  Copper type II ascorbate-dependent monooxygenase, N-terminal domain.
DOMON (pfam03351)
  DOMON domain.
Cu2_monoox_C (pfam03712)
  Copper type II ascorbate-dependent monooxygenase, C-terminal domain.
Cu2_monooxygen (pfam01082)
  Copper type II ascorbate-dependent monooxygenase, N-terminal domain.
Cu2_monoox_C (pfam03712)
  Copper type II ascorbate-dependent monooxygenase, C-terminal domain.
DOMON_like (cl14783)
  Domon-like ligand-binding domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dbh includes H.sapiens DBH and R.norvegicus Dbh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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